Mechano Growth Factor
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MGF is the native, non-pegylated IGF-1 splice variant (IGF-1Ec) that mechanically loaded muscle expresses locally after exercise. Its half-life is extremely short, so it is injected directly into trained muscle in the hope of driving localized repair. There is no human trial evidence for the injectable product; the rationale comes from the endogenous molecule's biology, and the pegylated version (PEG-MGF) has largely superseded it commercially.
