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Not medical advice

The Book of Peptides is not a clinic and not your doctor. We do not sell, prescribe, recommend, or personalize any compound, and no grade or ranking here is an endorsement. None of the compounds covered are approved for the uses described here by the U.S. FDA, Australia's Therapeutic Goods Administration (TGA), New Zealand's Medsafe, or the equivalent regulator in most other countries.

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Book Two · Combination protocols

Stacks & synergy

32 combination protocols — what the evidence and community practice say pairs with what, the mechanism behind why, and how scheduling shifts when compounds run together rather than solo. Grouped by goal.

Trusted byChromatest
Protocols
32
Categories
9
Compounds combined
71
Category
Category
Cognitive & Neuroprotective Stacks
T3 · Emerging
01

Semax + Selank

"Russian Nootropic Stack" · Semax + Selank

Pairs Semax's alerting, BDNF-driven cognitive lift with Selank's non-sedating anxiolysis, aiming for calm, sustained focus without stimulant jitteriness or benzo-style blunting. Commonly run by people who found Semax alone too activating, or Selank alone insufficiently stimulating.

SemaxSelankstack
Locked
T4 · Theoretical
02

DSIP + Epitalon (Sleep Architecture)

A sleep pairing aimed at the pineal/melatonin axis rather than at sedation: DSIP nightly for the sleep episode itself, Epitalon in short periodic courses on the theory of restoring an age-flattened nocturnal melatonin rhythm.

DSIPEpitalonstack
Locked
Kitchen-Sink Mega-Blends
T4 · Theoretical
01

KLOW

GHK-Cu + BPC-157 + TB-500 + KPV

Sold as an all-in-one soft-tissue repair blend for tendon, ligament, muscle, joint, and gut/gastric irritation, with the KPV addition specifically framed as layering systemic anti-inflammatory action on top of the GLOW (GHK-Cu + BPC-157 + TB-500) base formula. The appeal is a "repair timeline" narrative -- revascularize, recruit repair cells, rebuild matrix, then suppress the inflammation that would otherwise stall the process -- rather than any single compound addressing the whole chain.

GHK-CuBPC-157TB-500+1 moreblend
Locked
T4 · Theoretical
02

GLOW (GHK-Cu + BPC-157 + TB-500)

A three-peptide "regenerative" blend sold as the KPV-free predecessor to KLOW, marketed to cover surface skin quality and deeper soft-tissue repair at once: GHK-Cu for collagen/elastin remodeling, BPC-157 for localized tendon/ligament and gut-lining repair, and TB-500 for systemic cell-migration and anti-inflammatory support with reduced scarring.

GHK-CuBPC-157TB-500blend
Locked
T4 · Theoretical
03

The Mito Stack (SS-31 + MOTS-c + NAD+)

A mitochondria-themed longevity blend marketed for cellular energy, fatigue and "healthspan" rather than any one condition. Documented here as a marketed category: no specific fixed-ratio product, label or per-component milligram figure could be independently corroborated, and the trio has never been studied together.

SS-31MOTS-cNAD+ (nicotinamide adenine dinucleotideblend
Locked
T4 · Theoretical
04

GH Secretagogue Triple Blend

CJC-1295 (No DAC) + Ipamorelin + Tesamorelin

Layers Tesamorelin's on-label, trial-proven visceral-fat-reduction GHRH signal on top of the simpler CJC-1295+Ipamorelin GH-pulse stack, marketed as an escalation product for users who specifically want a fat-targeted GHRH agent added rather than just more of the same non-selective GHRH tone.

CJC-1295IpamorelinTesamorelinblend
Locked
Metabolic & Fat-Loss Stacks
T3 · Emerging
01

GLP-1 + GH Secretagogue (Muscle-Sparing)

Tirzepatide or Retatrutide + Tesamorelin

A persistent stacking question of the GLP-1 era: whether adding a growth-hormone secretagogue to tirzepatide or retatrutide blunts the lean-mass loss that comes with the weight loss. Trial data establishes the magnitude of that loss, not a drug-specific excess; the rest is untested community theory.

TirzepatideRetatrutideTesamorelin+2 morestack
Locked
T4 · Theoretical
02

GLP-1 + BPC-157 (GI Tolerance)

semaglutide / tirzepatide / retatrutide + BPC-157

The signature tolerance pairing of the GLP-1 era: BPC-157 run alongside semaglutide, tirzepatide or retatrutide in the hope of blunting the nausea, reflux and gut distress that dominate every GLP-1 trial's side-effect table — a gut-lining "protectant" under the compound doing the real work.

GLP-1-class agonistBPC-157stack
Locked
T1 · Established
03

CagriSema (Cagrilintide + Semaglutide)

A fixed 1:1 combination designed to produce superior, sustained weight loss (and, in type-2 diabetics, superior HbA1c reduction) versus either drug alone, by pairing two mechanistically distinct satiety pathways in one lockstep weekly regimen — this is Novo Nordisk's own designed and trial-tested purpose for the pairing, not a community-improvised stack.

CagrilintideSemaglutidehybrid
Locked
T4 · Theoretical
04

Cagrilintide + Tirzepatide

Stacks a long-acting amylin agonist onto tirzepatide's dual GIP/GLP-1 action, aiming to push fat-loss and metabolic-marker improvement beyond either compound alone, and in principle allowing lower per-drug doses for the same or better effect.

CagrilintideTirzepatidestack
Locked
T3 · Emerging
05

Retatrutide + Cagrilintide ("Quad-Pathway" stack)

Layers cagrilintide's amylin-pathway satiety signal onto retatrutide's triple GLP-1/GIP/glucagon mechanism to hit four non-overlapping metabolic pathways at once — the aim is greater total fat loss, more complete appetite control, and the option to run each compound at a lower, better-tolerated dose.

Retatrutide (LY3437943)Cagrilintidestack
Locked
T4 · Theoretical
06

Exercise-Mimetic Stack (5-Amino-1MQ + SLU-PP-332 + MOTS-c)

The non-incretin counter-position to the GLP-1 stacks: three compounds discussed together as an "exercise mimetic" — the pitch being that they switch on the muscle, mitochondrial and fat-oxidation gene programs aerobic training triggers, rather than working through appetite suppression. No co-formulated product combining all three is documented here.

5-Amino-1MQSLU-PP-332MOTS-cstack
Locked
T4 · Theoretical
07

The Layered Lipolysis Stack

Semaglutide/Tirzepatide/Retatrutide + AOD-9604

To layer adipocyte-level lipolysis on top of an existing weekly GLP-1/GIP agonist, chasing fat loss that doesn't depend on further appetite suppression — marketed as a "finishing phase" add-on for a stalled plateau or the last few stubborn pounds, not a starting-point protocol.

Semaglutide (or Tirzepatide, or Retatrutide)AOD-9604stack
Locked
Healing & Recovery Stacks
T4 · Theoretical
01

Wolverine Stack (BPC-157 + TB-500)

Marketed for accelerated soft-tissue and musculoskeletal healing — tendon, ligament, muscle, and joint injuries, plus post-surgical recovery — by pairing two peptides that vendor, clinic, and forum sources consistently describe as acting on different stages of the repair cascade rather than duplicating one another.

BPC-157TB-500stack
Locked
T4 · Theoretical
02

BPC-157 + KPV (Gut-Healing Duo)

A gut-specific pairing that combines a mucosal "repair" peptide with a targeted anti-inflammatory tripeptide, marketed for leaky gut, IBS, and IBD/colitis-adjacent symptoms rather than the tendon/ligament use case BPC-157 is better known for.

BPC-157KPVstack
Locked
T4 · Theoretical
03

PDA + TB-500 (The Post-Ban Wolverine)

Pentadeca Arginate + TB-500

The post-2023 rebuild of the "Wolverine stack" (BPC-157 + TB-500) — the same tendon/ligament and post-injury use case, with Pentadeca Arginate standing in for BPC-157 after the FDA's "do not compound" action. The substitution is what's new here, not the stack — see the Wolverine record for the shared mechanism.

Pentadeca ArginateTB-500stack
Locked
T4 · Theoretical
04

Gut Inflammation Trio

BPC-157 + KPV + Larazotide

An oral, three-mechanism gut-inflammation and intestinal-barrier ("leaky gut") support stack aimed at people with IBD-adjacent symptoms, food-reactivity, or post-NSAID/post-infectious gut irritation. The stacking rationale is division of labor: Larazotide is claimed to shore up the tight-junction barrier, KPV to calm the cytokine cascade already triggered, and BPC-157 to drive the underlying tissue repair — "prevent, calm, rebuild" rather than one compound doing all three jobs.

BPC-157KPVLarazotide acetate / AT-1001stack
Locked
GH Secretagogue Stacks
T3 · Emerging
01

Tesamorelin + Ipamorelin

Marketed to amplify and normalize the body's own nighttime growth-hormone pulses, in support of visceral-fat reduction, lean-mass-preserving recomposition, and recovery/skin quality — the two peptides are stacked because they act on two separate, complementary nodes of the GH-release axis rather than duplicating each other's effect.

Tesamorelin (Egrifta)Ipamorelinstack
Locked
T3 · Emerging
02

Sermorelin + GHRP-6

Pairs a GHRH analog with a ghrelin-mimetic GHRP, aiming to drive a stronger natural GH/IGF-1 pulse than either compound produces alone -- targeting muscle gain, fat loss, recovery, and sleep quality -- while GHRP-6 is specifically reported to add a pronounced appetite-stimulating effect useful for bulking (or, for some users, an unwanted side effect they'd rather avoid by switching to GHRP-2 or ipamorelin).

SermorelinGHRP-6stack
Locked
T3 · Emerging
03

CJC-1295 (no DAC) + Hexarelin

Pairs a GHRH-receptor agonist with the single most potent GHRP available to produce a genuinely synergistic (not just additive) GH pulse, for people already comfortable with solo GH secretagogues who want the strongest acute pulse this drug class can produce — accepting a short usable cycle window as the tradeoff.

CJC-1295Hexarelinstack
Locked
Muscle-Building Stacks
T4 · Theoretical
01

CJC-1295 (no DAC) + Ipamorelin

A GH-axis "base layer" stack that pairs a GHRH analog with a selective ghrelin-receptor agonist on the theory that, together, they raise endogenous GH/IGF-1 pulses more strongly than either compound alone — though no study has tested this exact pairing — aimed at recovery, sleep quality, and body composition rather than acting as a muscle-building compound in its own right.

CJC-1295Ipamorelinstack
Locked
T3 · Emerging
02

IGF-1 LR3 + CJC-1295/Ipamorelin

IGF-1 LR3 + CJC-1295 (no DAC) + Ipamorelin

A three-peptide "full GH/IGF-1 axis" stack meant to hit the same growth-signaling pathway from two directions at once: CJC-1295 + Ipamorelin are reported to drive a bigger, more frequent pulse of the body's own growth hormone (and the downstream IGF-1 rise that follows it), while IGF-1 LR3 is injected directly to activate IGF-1 receptors in trained muscle immediately, without waiting on the GH step — though no trial has tested this exact three-peptide stack.

IGF-1 LR3CJC-1295Ipamorelinstack
Locked
T3 · Emerging
03

MK-677 (Ibutamoren) + IGF-1 LR3

MK-677 + IGF-1 LR3

Pairs a daily oral GH-secretagogue (MK-677) that keeps systemic GH/IGF-1 chronically elevated with an injected IGF-1 analog (LR3) that delivers an acute, high-concentration local bolus post-workout — the idea being to cover both the "always-on" systemic baseline and the "spike-on-demand" local signal in one stack.

MK-677IGF-1 LR3stack
Locked
Longevity & Cellular Health Stacks
T3 · Emerging
01

Epitalon + GHK-Cu

Epitalon (Epithalon) + GHK-Cu

A "two-pathway" longevity pairing that couples Epitalon's proposed nuclear/genomic action (telomerase activity, chromatin, pineal-melatonin rhythm) with GHK-Cu's better-established extracellular-matrix and tissue-repair action (collagen synthesis, broad gene-expression modulation) — the pitch being that one covers "inside the nucleus" aging and the other covers "structural/dermal-repair" aging, so a general anti-aging user runs both to cover more ground than either alone.

Epitalon / EpithalonGHK-Custack
Locked
T3 · Emerging
02

Epitalon + Thymosin Alpha-1

Epitalon (Epithalon) + Thymosin Alpha-1 (TA1)

Cover two non-overlapping decline pathways at once: Epitalon targets the pineal/circadian-melatonin axis and proposed telomere biology, while Thymosin Alpha-1 targets thymic involution and age-related loss of T-cell immune competence. The pairing is chosen because each compound addresses a different system, not because either boosts the other.

EpitalonThymosin Alpha-1stack
Locked
T3 · Emerging
03

GHK-Cu + NAD+

GHK-Cu + NAD+ (or NMN/NR)

Pair two longevity compounds that work on completely separate biological layers — GHK-Cu remodeling skin/tissue collagen, NAD+ refueling mitochondrial energy and DNA-repair enzymes — so a single protocol addresses both skin/hair/wound quality and energy/cognition at once.

GHK-CuNAD+stack
Locked
T3 · Emerging
04

Thymalin + Epitalon (Khavinson Stack)

Thymalin + Epitalon (Epithalamin)

Pairs a thymic-immune bioregulator with a pineal-neuroendocrine bioregulator as a seasonal "two-axis" longevity course, run together because the founding human trial itself found the combination beat either compound alone on its mortality endpoint (2.5-fold combined vs. 2.0-2.1-fold for Thymalin alone and 1.6-1.8-fold for Epithalamin alone).

ThymalinEpitalon / Epithalaminstack
Locked
Sexual Health & Hormonal Stacks
T4 · Theoretical
01

"PT-141 + Melanotan II"

Pairs MT-2's broad melanocortin activation (tanning plus incidental libido) with PT-141's on-demand sexual-response boost — both hit the same receptor family, so this isn't really combining two different effects, and most experienced users report picking one or the other by season rather than truly stacking them for combined intensity.

PT-141Melanotan IIstack
Locked
T3 · Emerging
02

PT-141 (Bremelanotide) + Oxytocin + Tadalafil

PT-141 + Oxytocin + Tadalafil ("Olympus")

A three-lever "complete" sexual-wellness troche marketed to hit central desire (PT-141), emotional bonding/connection (oxytocin), and peripheral erectile blood flow (tadalafil) in a single as-needed dose — but forum reports on the actual compounded troche are notably more mixed than the vendor copy selling it.

PT-141 (Bremelanotide)OxytocinTadalafilblend
Locked
T3 · Emerging
03

Olympus (PT-141 + Oxytocin)

Bremelanotide 1-2mg + Oxytocin 20-40IU, sublingual, no tadalafil

Combines PT-141's central desire/arousal effect with oxytocin's bonding/intimacy effect in a single sublingual tablet, deliberately without a PDE5 inhibitor — for people whose complaint is low desire or emotional disconnection rather than erectile blood flow, or who want to avoid stacking a third agent onto bremelanotide's own transient blood-pressure effect.

BremelanotideOxytocinblend
Locked
Immune-Modulating Stacks
T4 · Theoretical
01

Thymosin Alpha-1 + LL-37

Broad-spectrum, "layered" immune support pairing a slow-acting adaptive-immune coordinator (Thymosin Alpha-1, which primes T-cells and NK cells over days-to-weeks) with a fast-acting innate antimicrobial (LL-37, which physically disrupts pathogen membranes on contact). Framed by users as seasonal/preventive support and an adjunct during active infection, not as treatment for any diagnosed disease.

Thymosin Alpha-1LL-37stack
Locked
T4 · Theoretical
02

Thymosin Alpha-1 + TB-500

Thymosin Alpha-1 + TB-500 (Thymosin Beta-4)

Pairs immune reconstitution with accelerated soft-tissue repair on the logic that the two jobs don't compete for the same biology — used for post-illness deconditioning, post-surgical recovery, and combined immunosenescence plus musculoskeletal decline. It is explicitly not a bodybuilding or performance stack.

Thymosin Alpha-1TB-500stack
Locked